ABSTRACT
@#Objective To observe the effects of electroacupuncture combined with edaravone on the conduction velocity of sciatic nerve and oxidative stress in rats with diabetic peripheral neuropathy. Methods 60 Sprague Dawley (SD) rats were included. 10 of them were selected as normal group. The other rats were modeled as diabetic peripheral neuropathy with streptozotocin. 48 of them were randomly selected and divided into electroacupuncture group (n=12), edaravone group (n=12), electroacupuncture + edaravone group (n=12), and model group (n=12). The threshold temperature for wave tail was tested, the levels of superoxidase dismutase (SOD) and malonaldehyde (MDA) were determined, and the conduction velocity of sciatic nerve were measured, before, and 4 and 8 weeks after modeling. Results 8 weeks after modeling, the conduction velocity and SOD increased in the electroacupuncture group, edaravone group and electroacupuncture+edaravone group compared with the model group (P<0.01), with the MDA decrease (P<0.01), while it was improved more in the electroacupuncture+edaravone group than in the electroacupuncture group or the edaravone group (P<0.01). Conclusion Both electroacupuncture and edaravone can inhibit oxidative stress and improve nerve conduction velocity of the sciatic nerve in rats with diabetic peripheral neuropathy, and it is more effective of combination.
ABSTRACT
@#Objective To evaluate the effects of comprehensive rehabilitation training on the patients with schizophrenia by Meta-analysis.Methods Articles were searched form PubMed (2001 to 2011), EMCC(1995 to 2011), CNKI(1989 to 2011), VIP(1989 to 2011), and CBM(1989 to 2011), which were randomized controlled trials (RCTs) or controlled clinical trials (CCTs) about comprehensive rehabilitation training for schizophrenia. Quality of included articles was assessed with Jadad Scale, and the available data were analyzed with RevMan 5.0 software. Results 596 related articles were identified, but only 16 eligible articles were included. All the trials were of low quality. Meta-analysis showed that compared comprehensive rehabilitation training could improve the scores of Positive and Negative Syndrome Scale (PANSS) [Weighted Mean Difference (WMD) =-9.21, 95% CI(-10.83, -7.59), Z=11.6, P<0.00001], activites of daily living (ADL) [WMD=-5.84, 95% CI(-8.74, -2.94), Z=3.94, P<0.0001], Nurses' Observation Scale for Inpatient Evaluation (NOSIE) total score [WMD=27.50, 95%CI(16.18,38.81), Z=4.76, P<0.00001] and total score of negative factors [WMD=-13.60, 95%CI(-22.41, -4.80),Z=3.03, P=0.002], compared with those in routine care/management group. There was no significant difference between both groups in Social Disability Screening Schedule (SDSS) [WMD=-2.50, 95% CI(-5.33, 0.33), Z=1.73, P=0.08] and NOSIE total positive factor score [WMD=15.00, 95%CI(-2.06, 32.06), Z=1.72, P=0.08]. Conclusion Comprehensive rehabilitation training can reduce the positive and negative symptoms, improving the ability of daily living and quality of life.